Surgical Treatment of Non-Iatrogenic Complications After Endoscopic Prosthetic Replacement of Distal Severely Stenotic Colorectal Tumors
DOI:
https://doi.org/10.14748/kyzqaz59Keywords:
peritonitis, perforation, endoprosthesis, stenotic colon carcinomasAbstract
Introduction: Colorectal cancer is a pressing issue in modern society and has seen significant growth in recent decades. Endoscopic prosthetics of severely stenotic distal colorectal carcinomas are among the most innovative and highly specialized methods of stent implantation in gastroenterology, indicated for stenotic colon carcinomas for the purpose of bridging to other therapies—chemotherapy/targeted therapy/subsequent surgical intervention—as well as in palliative patients assessed by an oncology committee for palliative and symptomatic care for the purpose of resolving the passage.
Aim: Analysis of institutional experience in the treatment of non-iatrogenic complications arising after usage of endoscopic prosthetics for distal stenosing carcinomas and assessment of surgical behavior has been conducted.
Materials and Methods: A retrospective, two-center observation of 2 clinical cases for the period February 2024–April 2025, based on diagnostic and anamnestic data, imaging and endoscopic examinations, a sample of surgical protocols, and results from postoperative follow-up of patients, reflected in the hospital information system of Acibadem City Clinic Mladost Hospital and Acibadem City Clinic Tokuda University Hospital, has been done.
Results: The observation includes two cases of late complications, manifested in the development of local abscess, perforation, and fecal peritonitis. Both patients had secondary hematogenous dissemination and local peritoneal carcinomatosis, with stenting serving as a bridging to other therapies—chemotherapy/targeted therapy. The intraoperative finding concluded fecal peritonitis as a result of non-iatrogenic perforation of the intestine in the stenting area, caused by the intensive growth of the tumor and the development of local ischemia and necrosis of the pathological segment.
Discussion: In patients with decompensated vital functions and severe comorbidity, a combination of conservative procedures is indicated, including stenting of stenotic tumors, which ensures restoration of passage, improves the general condition of the patient, does not require removal of the stomach, and removes the necessity of urgent surgical intervention, while providing the opportunity for full surgical treatment at a later date.
Conclusion: Properly identifying the alternative solutions for low colon obstruction lowers the risk of complications. However, usage of endoscopic prosthetics combined with growth of the tumor may be the cause for other sever complications, therefor this method is to be applied on case-by-case basis, after assessing the benefits and risks for the patient.
References
[1] Zhang Y, Shi J, Shi B, et al. Self-expanding metallic stent as a bridge to surgery versus emergency surgery for obstructive colorectal cancer: a meta-analysis. Surg Endosc. 2012 Jan;26(1):110-9. doi: 10.1007/s00464-011-1835-6.
[2] Keymling M. Colorectal stenting. Endoscopy. 2003 Mar;35(3):234-8. doi: 10.1055/s-2003-37265.
[3] Trompetas V. Emergency management of malignant acute left-sided colonic obstruction. Ann R Coll Surg Engl. 2008 Apr;90(3):181-6. doi: 10.1308/003588408X285757.
[4] Small AJ, Coelho-Prabhu N, Baron TH. Endoscopic placement of self-expandable metal stents for malignant colonic obstruction: long-term outcomes and complication factors. Gastrointest Endosc. 2010 Mar;71(3):560-72. doi: 10.1016/j.gie.2009.10.012.
[5] Arenas RB, Fichera A, Mhoon D, et al. Incidence and therapeutic implications of synchronous colonic pathology in colorectal adenocarcinoma. Surgery. 1997 Oct;122(4):706-9; discussion 709-10. doi: 10.1016/s0039-6060(97)90077-5.
[6] Miyayama S, Matsui O, Kifune K, et al. Malignant colonic obstruction due to extrinsic tumor: palliative treatment with a self-expanding nitinol stent. AJR Am J Roentgenol. 2000 Dec;175(6):1631-7. doi: 10.2214/ajr.175.6.1751631.
[7] Leitman IM, Sullivan JD, Brams D, et al. Multivariate analysis of morbidity and mortality from the initial surgical management of obstructing carcinoma of the colon. Surg Gynecol Obstet. 1992 Jun;174(6):513-8.
[8] Dharmadhikari R, Nice C. Complications of colonic stenting: a pictorial review. Abdom Imaging. 2008 May-Jun;33(3):278-84. doi: 10.1007/s00261-007-9240-2
[9] Abbott S, Eglinton TW, Ma Y, et al. Predictors of outcome in palliative colonic stent placement for malignant obstruction. Br J Surg. 2014 Jan;101(2):121-6. doi: 10.1002/bjs.9340.
[10] Jung MK, Park SY, Jeon SW, et al. Factors associated with the long-term outcome of a self-expandable colon stent used for palliation of malignant colorectal obstruction. Surg Endosc. 2010 Mar;24(3):525-30. doi: 10.1007/s00464-009-0604-2.
[11] Athreya S, Moss J, Urquhart G, et al. Colorectal stenting for colonic obstruction: the indications, complications, effectiveness and outcome--5 year review. Eur J Radiol. 2006 Oct;60(1):91-4. doi: 10.1016/j.ejrad.2006.05.017.
[12] Maruthachalam K, Lash GE, Shenton BK, et al. Tumour cell dissemination following endoscopic stent insertion. Br J Surg. 2007 Sep;94(9):1151-4. doi: 10.1002/bjs.5790.
[13] Keswani RN, Azar RR, Edmundowicz SA, et al. Stenting for malignant colonic obstruction: a comparison of efficacy and complications in colonic versus extracolonic malignancy. Gastrointest Endosc. 2009 Mar;69(3 Pt 2):675-80. doi: 10.1016/j.gie.2008.09.009.
[14] Choi JH, Lee YJ, Kim ES, et al. Covered self-expandable metal stents are more associated with complications in the management of malignant colorectal obstruction. Surg Endosc. 2013 Sep;27(9):3220-7. doi: 10.1007/s00464-013-2897-4.
[15] Binkert CA, Ledermann H, Jost R, et al. Acute colonic obstruction: clinical aspects and cost-effectiveness of preoperative and palliative treatment with self-expanding metallic stents--a preliminary report. Radiology. 1998 Jan;206(1):199-204. doi: 10.1148/radiology.206.1.9423673.
[16] Khot UP, Lang AW, Murali K, et al. Systematic review of the efficacy and safety of colorectal stents. Br J Surg. 2002 Sep;89(9):1096-102. doi: 10.1046/j.1365-2168.2002.02148.x.
[17] Mainar A, Tejero E, Maynar M, et al. Colorectal obstruction: treatment with metallic stents. Radiology. 1996 Mar;198(3):761-4. doi: 10.1148/radiology.198.3.8628867.
[18] Lopera JE, Ferral H, Wholey M, et al. Treatment of colonic obstructions with metallic stents: indications, technique, and complications. AJR Am J Roentgenol. 1997 Nov;169(5):1285-90. doi: 10.2214/ajr.169.5.9353443.
[19] Suzuki N, Saunders BP, Thomas-Gibson S, et al. Colorectal stenting for malignant and benign disease: outcomes in colorectal stenting. Dis Colon Rectum. 2004 Jul;47(7):1201-7. doi: 10.1007/s10350-004-0556-5.